JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine.

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Chronic pulmonary thromboembolic disease
Abstract
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), defined as precapillary pulmonary hypertension (PH) with right heart catheterization and imaging consistent with chronic thromboembolism, is a long-term complication of Pulmonary Embolism (PE). CTEPH defines symptomatic patients with maladaptive perfusion disorders after at least 3 months of therapeutic anticoagulation. In this setting, pulmonary hypertension results from extensive Pulmonary Artery (PA) obstruction by only organized fibrotic clots and may also be present as micro vasculopathy. Echocardiographic (ECHO) examination to determine a pulmonary surgical operation if the patient complains of anticipation and/or the risk for CTEPH is widely demonstrated (prior PE episodes, existing imaging size as index event suggestive of CTEPH, key features such as hypothyroidism and cancer), It is the preferred recognition method because of its availability and the high data value and amount of data. Patients diagnosed with CTEPH or with a strong suspicion of CTEPH should be referred to a specialist pulmonary cardiovascular clinic for further multidisciplinary diagnosis and treatment, such as Pulmonary Endarterectomy (PEA), balloon Pulmonary Angioplasty (BPA), and/or Targeted pulmonary medical therapy. In recent years, significant progress has been made in evaluating patients with sequelae after a pulmonary embolism, confirming clinical, biochemical, and hemodynamic criteria. Further work is needed to elucidate and develop appropriate standing protocols to support limited purposes and ongoing archives to ensure physical care capacity and life security.

Keywords : Chronic pulmonary thromboembolic disease, pulmonary hypertension, vasculopathy

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1. Le Gal G, Carrier M, Castellucci LA, et al. Development andimplementation of common data elements for venous thromboembolismresearch: on behalf of SSC Subcommittee on official Communicationfrom the SSC of the ISTH. J Thromb Haemost. 2021;19(1):297-303.
2. Humbert M, Kovacs G, Hoeper MM, et al. 2022 ESC/ERS Guidelines forthe diagnosis and treatment of pulmonary hypertension. Eur Heart J.2022; 43(38): 3618-3731.
3. Delcroix M, Torbicki A, Gopalan D, et al. ERS statement onchronic thromboembolic pulmonary hypertension. Eur Respir J.2021;57(6):2002828. doi:10.1183/13993003.02828-2020
4. Delcroix M, Kerr K, Fedullo P. Chronic thromboembolic pulmonaryhypertension. Epidemiology and risk factors. Ann Am Thorac Soc. 2016;13(Suppl 3):201-206.
5. Ende-Verhaar YM, Cannegieter SC, Vonk Noordegraaf A, et al.Incidence of chronic thromboembolic pulmonary hypertension afteracute pulmonary embolism: a contemporary view of the publishedliterature. Eur Respir J. 2017;49(2):1601792.
6. Kerr KM, Elliott CG, Chin K, et al. Results from the United Stateschronic thromboembolic pulmonary hypertension registry: enrollmentcharacteristics and 1-year follow-up. Chest. 2021;160(5):1822-1831.
7. Kahn SR, Hirsch AM, Akaberi A, et al. Functional and exerciselimitations after a first episode of pulmonary embolism: results of theELOPE prospective cohort study. Chest. 2017;151(5):1058-1068.
8. Newnham M, South K, Bleda M, et al. The ADAMTS13-VWF axis isdysregulated in chronic thromboembolic pulmonary hypertension. EurRespir J. 2019;53(3):1801805.
9. Teerapuncharoen K, Bag R. Chronic thromboembolic pulmonaryhypertension. Lung. 2022;200(3):283-299.
10. Humbert M, Guignabert C, Bonnet S, et al. Pathology and pathobiologyof pulmonary hypertension: state of the art and research perspectives.Eur Respir J. 2019;53(1):1801887.
11. Braganza M, Shaw J, Solverson K, et al. A prospective evaluation ofthe diagnostic accuracy of the physical examination for pulmonaryhypertension. Chest. 2019;155(5):982-990.
12. He J, Fang W, Lv B, et al. Diagnosis of chronic thromboembolicpulmonary hypertension: comparison of ventilation/perfusionscanning and multidetector computed tomography pulmonaryangiography with pulmonary angiography. Nucl Med Commun. 2012;33(5):459-463.
13. Lang IM, Campean IA, Sadushi-Kolici R, Badr-Eslam R, GergesC, Skoro-Sajer N. Chronic thromboembolic disease and chronicthromboembolic pulmonary hypertension. Clin Chest Med. 2021;42(1):81-90.
14. Hsieh WC, Jansa P, Huang WC, Niznansky M, Omara M, LindnerJ (2018) Residual pulmonary hypertension after pulmonaryendarterectomy: a meta-analysis. J Thorac Cardiovasc Surg. 2018;156(3):1275-1287.
15. Zoppellaro G, Badawy MR, Squizzato A, Denas G, Tarantini G,Pengo V. Balloon pulmonary angioplasty in patients with chronicthromboembolic pulmonary hypertension: a systematic review andmeta-analysis. Circ J. 2019; 83(8):1660-1667.
16. Kawakami T, Matsubara H, Abe K, et al. Multicentre randomisedcontrolled trial of balloon pulmonary angioplasty and riociguat inpatients with chronic thromboembolic pulmonary hypertension:protocol for the MR BPA study. BMJ Open. 2020;10(2):e028831.
17. Ghofrani HA, D’Armini AM, Grimminger F, et al. Riociguat for thetreatment of chronic thromboembolic pulmonary hypertension. N EnglJ Med. 2013; 369(4):319-329.
18. Sadushi-Kolici R, Jansa P, Kopec G, et al. Subcutaneous treprostinilfor the treatment of severe non-operable chronic thromboembolicpulmonary hypertension (CTREPH): a double-blind, phase 3,randomised controlled trial. Lancet Respir Med. 2019;7(3):239-248.
Article available in :
Volume 1, Issue 3, 2023
Page : 70-72
https://doi.org/10.51271/JOPIC-0016
Article Information
Received : 24 Tem 2023
Accepted : 26 Ağu 2023
Published : 29 Ağu 2023
Corresponding Author :

Nalan Ogan: Deparment of Chest Diseases, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Ogan N, İlgar C. Chronic pulmonary thromboembolic disease. J Pulmonol Intens Care. 2023;1(3):70-72

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