JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Role of serum melatonin level in COVID-19 mortality and hospital admission
Abstract
Aims: Coronavirus Disease 2019 (COVID-19) is a virus zoonotic in nature, which presents itself with a broad spectrum of respiratory involvement. Without any specific treatment, various treatment modalities and markers for severity have been suggested. This study aimed to investigate the role of melatonin in the severity of COVID-19 infection, with the hypothesis that melatonin levels correlated with mortality, ward and intensive care unit (ICU) admission.
Methods: The study was performed as a single-center prospective cohort. Patients who had been evaluated at the emergency ward for COVID-19 suspicion were defined as the study population. Those who had at least one COVID-19 RT-PCR positivity and did not have a history of cranial operation, being a shift worker, or under melatonin treatment were chosen. Ninety-six patients were deemed suitable for the study who had all the criteria fulfilled. Descriptive analysis for demographic data, Spearman correlation, and Mann-Whitney test for nonparametric evaluation was used.
Results: Eighty patients were considered suitable after excluding 16 patients, primarily due to improper melatonin sampling times. A positive correlation was seen between melatonin levels and intensive care admission, which was not observed in ward admission or overall mortality. This implicates the possibility of melatonin being used as a marker for the severity analysis of COVID-19.
Conclusion: With limited sensitivity, melatonin may be used for the evaluation of ICU admission. Its role in ward admission and overall mortality remains limited.

Keywords : Critical care, COVID-19, melatonin, mortality

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1. Zhou Y, Hou Y, Shen J, et al. Network-based drug repurposing for novelcoronavirus 2019-nCoV/SARS-CoV-2. Cell Discovery. 2020;6(1):14. doi.org/10.1038/s41421-020-0153-3
2. Muxel SM, Pires-Lapa MA, Monteiro AWA, et al. NF-κB drives thesynthesis of melatonin in RAW 264.7 macrophages by inducingthe transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS One. 2012;7(12):e52010. doi.org/10.1371/journal.pone.0052010
3. Reiter RJ, Sharma R, Ma Q, et al. Inhibition of mitochondrial pyruvatedehydrogenase kinase: a proposed mechanism by which melatonincauses cancer cells to overcome cytosolic glycolysis, reduce tumorbiomass and reverse insensitivity to chemotherapy. Melatonin Res.2019;2(3):105-119. doi.org/10.32794/mr11250033
4. Acuña-Castroviejo D, Noguiera-Navarro MT, Reiter RJ, et al. Melatoninactions in the heart; more than a hormone. Melatonin Res. 2018;1(1):21-26.doi.org/10.32794/mr11250002
5. Biancatelli RMLC, Berrill M, Mohammed YH, et al. Melatonin forthe treatment of sepsis: The scientific rationale. J Thoracic Disease.2020;12(1):54-65. doi.org/10.21037/jtd.2019.12.85
6. Boga JA, Coto-Montes A, Rosales-Corral SA, et al. Beneficial actionsof melatonin in the management of viral infections: a new use for this“molecular handyman”? Rev Med Virology. 2012;22(5):323-338. doi.org/10.1002/rmv.1714
7. Reiter RJ, Ma Q, Sharma R. Treatment of ebola and other infectiousdiseases: melatonin “goes viral.” Melatonin Res. 2020;3(1):43-57. doi.org/10.32794/mr11250047
8. Hsing AW, Meyer TE, Niwa S, et al. Measuring serum melatonin inepidemiologic studies. Cancer Epidemiology Biomarkers Prevention.2010;19(4):932-937. doi.org/10.1158/1055-9965.EPI-10-0004
9. Dinicolantonio JJ, McCarty M, Barroso-Aranda J. Melatonin maydecrease risk for and aid treatment of COVID-19 and other RNAviral infections. Open Heart. 2021;8(1):e001568. doi.org/10.1136/openhrt-2020-001568
10. García IG, Rodriguez-Rubio M, Mariblanca AR, et al. A randomizedmulticenter clinical trial to evaluate the efficacy of melatonin in theprophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVIDTrial): a structured summary of a study protocol for a randomisedcontrolled trial. Trials. 2020;21:1-4. doi.org/10.1186/s13063-020-04436-6
11. Ameri A, Asadi MF, Kamali M, et al. Evaluation of the effect ofmelatonin in patients with COVID-19-induced pneumonia admittedto the intensive care unit: a structured summary of a study protocolfor a randomized controlled trial. Trials. 2021;22:1-2. doi.org/10.1186/s13063-021-05162-3
12. Anderson G, Reiter RJ. Melatonin: roles in influenza, COVID-19,and other viral infections. Rev Med Virology. 2020;30(3):e2109. doi.org/10.1002/rmv.2109
Article available in :
Volume 1, Issue 4, 2023
Page : 91-95
https://doi.org/10.51271/JOPIC-0021
Article Information
Received : 03 Eyl 2023
Accepted : 10 Eki 2023
Published : 24 Eki 2023
Corresponding Author :

Kerem Ensarioglu: Department of Chest Diseases, Ankara Atatürk Sanatorium Training and Research Hospital, University of Health Sciences, Ankara, Turkiye

[email protected]
Citation : Yılmaz Aydın Y, Yurtseven A, Ensarioğlu K, et al. Role of serum melatonin level in COVID-19 mortality and hospital admission. J Pulmonol Intens Care 2023;1(4):91-95.

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