JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

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Original Article
Diagnostic and prognostic value of serum amiloid a in patients with idiopatic pulmonary fibrosis
Abstract
Aims: the aim of our study was to investigate the diagnostic and prognostic value of SAA and its usability as a biomarker in patients with IPF.
Methods: This study has been designed as a prospective, case-control study. Fifteen healthy individuals and 15 IPF patients. The demographic data and the measures from PFT, DLCO, laboratory tests of the patients included in the study were retrieved from IPF follow-up files.
Results: The comparison of the IPF patient group with the group of healthy volunteers revealed significantly higher SAA values in IPF patients (p:0.005). A significant positive correlation was found between the patients' SAA and C-Reactive Protein (CRP) values. A negative significant correlation was found between the SAA values of the patients and the time to diagnosis (p<0.05). Despite the negative correlation between the SAA and FVC values of patients, no significant correlations were detected between these variables (p>0.05). This result suggests that SAA levels would be higher in newly or recently diagnosed .
Conclusion: This study shows that SAA is significantly higher in IPF patients, suggesting that it will be a reliable biomarker feasible to predict the diagnosis. Future studies with larger patient groups ara needed.

Keywords : Fibrosis , biomarker, prognosis

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Article available in :
Volume 2, Issue 1, 2024
Page : 1-5
https://doi.org/10.51271/JOPIC-0024
Article Information
Received : 17 Eki 2023
Accepted : 14 Ara 2023
Published : 13 Şub 2024
Corresponding Author :

Selma Yalçın: Fatsa State Hospital, Ordu, TURKEY

[email protected]
Citation : Yalçın S, Yüceege MB, Kurt EB. Diagnostic and prognostic value of serum amiloid a in patients with idiopatic pulmonary fibrosis. J Pulmonol Intens Care. 2024;2(1):1-5.

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