JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

eISSN: 2980-0803
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
An evaluation of noninvasive mechanical ventilation application in intensive care
Abstract
Aims: Noninvasive mechanical ventilation (NIMV) is a positive pressure treatment applied with a mask without the need for endotracheal intubation in patients with acute and chronic respiratory failure. C-reactive protein (CRP), procalcitonin (PCT), albumin, red blood cell distribution width (RDW), and mean platelet volume (MPV) are frequently used markers in clinical practice. Arterial blood gas (ABG) analysis is a standard method in clinical practice in intensive care, which is known to have a higher risk of complications than venous blood gas (VBG) analysis. Studies have shown a strong correlation between ABG and VBG with regard to pH, partial arterial carbon dioxide pressure (PCO2), and serum bicarbonate (HCO3). In this study, we aimed to evaluate the relationship between CRP, PCT, albumin, MPV, and RDW and in-hospital mortality and acute respiratory failure in patients undergoing NIMV. Our secondary aim was to evaluate the relationship between these parameters and VBG values.
Methods: Patients with acute hypoxemic and hypercapnic respiratory failure that underwent NIMV in intensive care unit (ICU) were evaluated retrospectively.
Results: The study included 99 patients with a mean age of 69.39±9.79 years. In-hospital mortality occurred in 5 (5.1%) patients. Hypercapnic respiratory failure was detected in 66 (66.7%), hypoxemic respiratory failure in 19 (19.2%), and hypoxemic + hypercapnic respiratory failure in 14 (14.1%) patients. PCT was significantly higher in patients with acute hypoxemic respiratory failure and MPV was significantly higher in patients with acute hypercapnic respiratory failure compared to other patients (p<0.05 for both). Both MPV and RDW were significantly higher in patients with in-hospital mortality (p<0.05). The baseline and 24-h PO2/FiO2 ratios were significantly lower in patients with acute hypoxemic + hypercapnic respiratory failure (p<0.05). The 24-h PO2/FiO2 ratio was significantly lower in patients with in-hospital mortality compared to patients without mortality (p<0.05).
Conclusion: Both RDW and MPV should be employed in predicting mortality in patients undergoing NIMV due to acute respiratory failure. Further multicenter, prospective studies are needed to evaluate the PaO2/FiO2 ratio particularly in VBG in patients receiving NIMV due to acute respiratory failure.

Keywords : Noninvasive mechanical ventilation, venous blood gas, red blood ell distribution width , mean platelet volume

Download Article


1. Lin SH, He YP, Lian JJ, Chu CK. Procalcitonin kinetics to guidesequential invasive-noninvasive mechanical ventilation weaning inpatients with acute exacerbation of chronic obstructive pulmonarydisease and respiratory failure: procalcitonin&rsquo;s adjunct role. Libyan JMed. 2021;16(1):1961382.
2. Chawla R, Dixit SB, Zirpe KG, et al. ISCCM guidelines for the use ofnon-invasive ventilation in acute respiratory failure in adult ICUs.Indian J Crit Care Med. 2020;24(Suppl 1):S61-S81.
3. Paone G, Conti V, Biondi-Zoccai G, et al. Long-term home noninvasivemechanical ventilation increases systemic inflammatory response inchronic obstructive pulmonary disease: a prospective observationalstudy. Mediators Inflamm. 2014;2014:503145.
4. &Ccedil;iledağ A, Kaya A, Diken &Ouml;E, &Ouml;nen ZP, Şen E, Demir N. The riskfactors for late failure of non-invasive mechanical ventilation in acutehypercapnic respiratory failure. Tuber Toraks. 2014;62(3):177-182.
5. Wang J, Shang H, Yang X, Guo S, Cui Z. Procalcitonin, C-reactiveprotein, PaCO2, and noninvasive mechanical ventilation failurein chronic obstructive pulmonary disease exacerbation. Medicine.2019;98(17):e15171.
6. Zheng Y, Luo Z, Cao Z. Mean platelet volume is useful for predictingweaning failure: a retrospective, observational study. BMC Anesthesiol.2022;22(1):160.
7. Han YQ, Zhang L, Yan L, et al. Red blood cell distribution widthpredicts long-term out-comes in sepsis patients admitted to theintensive care unit. Clin Chim Acta. 2018;487:112-116.
8. Kelly AM, McAlpine R, Kyle E. Venous pH can safely replace arterialpH in the initial evaluation of patients in the emergency department.Emerg Med J. 2001;18(5):340-342.
9. Ak A, Ogun CO, Bayir A, Kayis SA, Koylu R. Prediction of arterialblood gas values from venous blood gas values in patients with acuteexacerbation of chronic obstructive pulmonary disease. Tohoku J ExpMed. 2006;210(4):285-290.
10. Falc&atilde;o ALE, Barros AGA, Bezerra AAM, et al. The prognostic accuracyevaluation of SAPS 3, SOFA and APACHE II scores for mortalityprediction in the surgical ICU: an external validation study anddecision-making analysis. Ann Intensive Care. 2019;9(1):18.
11. Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinicalpractice guidelines: noninvasive ventilation for acute respiratoryfailure. Eur Respir J. 2017;50(2):1602426.
12. Carvalho EB, Leite TRS, Sacramento RFM, et al. Rationale andlimitations of the SpO2/FiO2 as a possible substitute for PaO2/FiO2in different preclinical and clinical scenarios. Rev Bras Ter Intensiva.2022;34(1):185-196.
13. Spada C, Gandhi R, Patel SR, Nuccio P, Weinhouse GL, Lee PS. Oxygensaturation/fraction of inspired oxygen ratio is a simple predictor ofnoninvasive positive pressure ventilation failure in critically ill patients.J Crit Care. 2011;26(5):510-516.
14. Adams JY, Rogers AJ, Schuler A, et al. Association between peripheralblood oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2)ratio time at risk and hospital mortality in mechanically ventilatedpatients. Perm J. 2020;24:19.113.
15. Mart&iacute;n-Rodr&iacute;guez F,L&oacute;pez-Izquierdo R,del Pozo Vegas C, et al.Association of prehospital oxygen saturation to inspired oxygen ratiowith 1-, 2-, and 7-day mortality.JAMA Netw Open.2021;4(4):e215700.
16. Wang J, Bian S, Tang X, Ye S, Meng S, Lei W. Influencing factorsof noninvasive positive pressure ventilation in the treatment ofrespiratory failure: a 10-year study in one single center. Eur J Med Res.2021;26(1):136.
17. Ling M, Huiyin L, Shanglin C, et al. Relationship between humanserum albumin and in-hospital mortality in critical care patients withchronic obstructive pulmonary disease. Front Med. 2023;10:1109910.
18. Chen C, Chen Y, Lu C, et al. Severe hypoalbuminemia is a strongindependent risk factor for acute respiratory failure in COPD: anationwide cohort study. Int J Chronic Obstr. 2015;10:1147-1154.
19. Daubin C, Parienti JJ, Vabret A, et al. Procalcitonin levels in acuteexacerbations of COPD admitted in ICU: a prospective cohort study.BMC Infect Dis. 2008;8:145.
20. Rammaert B, Verdier N, Cavestri B, et al. Procalcitonşn as a prognosticfactor in severe acute exacerbation of chronic obstructive pulmonarydisease. Respirology. 2009;14(7):969-974.
21. Bhattacharya B, Prashant A, Vishwanath P, Suma MN, Nataraj B.Prediction of outcome and prognosis of patients on mechanicalventilation using body mass index, SOFA score, C-reactive protein, andserum albumin. Indian J Crit Care Med. 2011;15(2):82-87.
22. Leuzzi G, Galeone C, Taverna F, Suatoni P, Morelli D, Pastorino U.C-reactive protein level predicts mortality in COPD: a systematicreview and meta-analysis. Eur Respir Rev. 2017;26(143):160070.
23. Chen J, Li Y, Zeng Y, Tian Y, Wen Y, Wang Z. High mean plateletvolume associates with in-hospital mortality in severe pneumoniapatients. Mediators Inflamm. 2020;2020:8720535.
24. Kim CH, Park JT, Kim EJ, et al. An increase in red blood celldistribution width from baseline predicts mortality in patients severepatients with severe sepsis or septic shock. Crit Care. 2013;17(6):R282.
25. Farghly S, Abd-Elkader R, El Zohne RA, Abd El-Kareem DM. Meanplatelet volume change (?MPV) and red blood cell distribution width(RDW) as promising markers of community-acquired pneumonia(CAP) outcome. Egypt J Bronchol. 2020;14(1):23.
Article available in :
Volume 2, Issue 2, 2024
Page : 27-32
https://doi.org/10.51271/JOPIC-0031
Article Information
Received : 15 Nis 2024
Accepted : 04 May 2024
Published : 23 May 2024
Corresponding Author :

Derya Hoşgün: Department of Intensive Care Unit, Atatürk Sanatoryum Training and Research Hospital, Ankara, Turkiye

[email protected]
Citation : Karatepe Ü, Afşar Karatepe B, Hoşgün D. An evaluation of noninvasive mechanical ventilation application in intensive care. J Pulmonol Intens Care. 2024;2(2):27-32.

Read: 373
Cited: 0
Download : 242
_Footer