JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine. This journal is indexed by indices that are considered international scientific journal indices (DRJI, ESJI, OAJI, etc.). According to the current Associate Professorship criteria, it is within the scope of International Article 1-d. Each article published in this journal corresponds to 5 points.

eISSN: 2980-0803
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
The relationship between obstructive sleep apnea syndrome severity and vitamin D levels in sera
Abstract
Aims: Obstructive Sleep Apnea Syndrome (OSAS) is a disorder characterized by complete or partial upper airway obstruction episodes and frequently decreased arterial oxygen saturation. Etiological factors and risk factors of OSAS are still investigated and studies in this topic continue. Until recently, researches were focused on the major effects of vitamin D on the bone metabolism and calcium homeostasis. Today; it has been found that vitamin D plays roles in many cells and tissues of human body additional to its functions in the musculoskeletal system. In our study, we aimed to examine vitamin D levels in patients who are diagnosed as OSAS and to investigate the relationship between OSAS and vitamin D deficiency.
Methods: 83 volunteers, who were suspected to have OSAS, were included in the study. They all underwent polysomnography (PSG) in the Sleep Disorders Center in Pulmonary Department, between January 2015 – May 2015. Twenty cases with apnea hypopnea index (AHİ) < 5/hour were evaluated as simple snoring/control group. Cases with AHİ > 5/hour were diagnosed as OSAS; 22 patients were diagnosed as mild, 20 patients were diagnosed as moderate and 21 patients were diagnosed as severe OSAS. Blood samples of these patients were studied for the measurement of vitamin D [25(OH)D3], parathormone (PTH) , calcium (Ca), phosphor (P) levels and the samples were quickly delivered to biochemistry laboratory
Results: A statistically significant difference in vitamin D levels were observed (p<0.05) between the control and OSAS groups. However, no statistically significant difference was found in PTH, Ca, P levels among these groups (p>0.05). Vitamin D levels in the control group were significantly higher than the mild and the severe OSAS patients. No statistically significant difference was observed in PTH, Ca, P levels between these patients.
Conclusion: Our study indicates that there is a significant relationship between vitamin D deficiency and OSAS. This finding suggests that vitamin D deficiency may play a role in the OSAS physiopathology. There are few studies exists about the association between vitamin D deficiency and OSAS. In this regard, we think our study will contribute to the literature. Moreover; prospective, randomized, controlled studies with large series were needed.

Keywords : Obstructive sleep apnea syndrome, vitamin D, parathormone, calcium, phosphor

Download Article


1. Buysse DJ. International classification of sleep disorders, version 2:diagnostic coding manual.American Academy Of Sleep Medicine,Rochester. 2005.
2. Silva GE, Goodwin JL, Vana KD, Quan SF. Obstructive sleep apneaand quality of life: comparison of the SAQLI, FOSQ, and SF-36questionnaires. Southwest J Pulm Crit Care. 2016;13(3):137-149.
3. Al Lawati NM, Patel SR, Ayas NT. Epidemiology, risk factors, andconsequences of obstructive sleep apnea and short sleep duration. ProgCardiovasc Dis. 2009;51(4):285-293.
4. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apneain adults. JAMA. 2004;29(16):6.
5. Iber C. Israel AS, Chesson AL, Quan SF. The AASM manual for thescoring of sleep and associated events. Rules, terminology and technicalspecifications. 1st ed: wenchester, Illıonis: American Academy Of SleepMedicine. 2007.
6. Yavuz D, Mete T, Yavuz R, Altunoğlu A. D Vitamini, calsiyum,mineral metabolizması, D vitaminin iskelet dışı etkileri ve kronikb&ouml;brek yetmezliğinde n&uuml;trisyonel D vitamini kullanımı. AnkMJ.2014;14(4):162-171.
7. Skaaby T, Husemoen LLN, Thuesen BH, et al. Vitamin D statusand chronic obstructive pulmonary disease: a prospective generalpopulation study. PloS one. 2014;9(3):90654.
8. Persson LJP, Aanerud M, Hiemstra PS, et al. Chronic obstructivepulmonary disease is associated with low levels of vitamin D. PLoS One.2012;7(6):38934.
9. David E, McCarty M, Andrew L et al. The link between vitamin Dmetabolism and sleep medicine. Sleep Med Rev. 2014;18(4):311-319.
10. Jennum P. Sj&Oslash;l A. Epidemiology of snoring and obstructive sleepapnoea in a danish population, age 30-60. J sleep Res. 1992;1(4):240-244.
11. &Ccedil;ift&ccedil;i B. Bakmak ve g&ouml;rmek; uykuda solunum bozukluğu-hekimfarkındalığı. 2009;19(3):95-98.
12. Banno K, Kryger MH. Sleep apnea: clinical investigations in humans.Sleep Med Rev. 2007;8(4):400-426.
13. Nieto FJ, Young TB, Shahar E, et al. Association of sleep-disorderedbreathing, sleep apnea, and hypertension in a large community-basedstudy. JAMA. 2000;283(14):1829-1836.
14. S&ouml;zen T. D hormon: g&uuml;ncel gelişmeler. Hacettepe Tıp Derg. 2011;42(1):14-27.
15. K&ouml;kt&uuml;rk O. Obstr&uuml;ktif uyku apne sendromu fizyopatolojisi. TurkToraks Derneği merkezi kurslar. Turk Thorac J. 2007;27(1)71-82.
16. Hoffstein V, Mateika S. Differences in abdominal and neckcircumferences in patients with and without obstructive sleep apnoea.Eur Respir J. 1992;5(4):377-381.
17. Uyar M. et al. Clinical profiles of obstructive sleep apnea syndrome.Turk Thorac J. 2008;9(3):113.
18. Holick MF. McCollum award lecture, 1994: vitamin D-new horizonsfor the 21st century. Am J Clin Nutr. 1994;60(4):619-630.
19. Jameson JL, Weetman AP. Tiroid bezi hastalıkları. Harrison İ&ccedil;hastalıkları prensipleri (15. Edisyon). İstanbul: Nobel Matbaacılık.2004;4(1):2060-2075.
20. Bordelon P, Ghetu MV, Langan R. Recognition and management ofvitamin D deficiency. Am Fam Physician. 2009;15(80):841-846.
21. Mete T, Yal&ccedil;ın Y, Berker D, et al. Obstructive sleep apnea syndromeand its association with vitamin D deficiency. J Endocrinol Invest.2013;36(9):681-685.
22. Bozkurt NC, &Ccedil;akal E, Şahin M, et al. The relation of serum 25hydroxyvitamin D levels with severity of obstructive sleep apnea andglucose metabolism abnormalities. Endocrine. 2012;41(3):518-525.
23. Barcelo A, Esquinas C, Pierola J, et al. Vitamin D status and parathyroidhormone levels in patients with obstructive sleep apnea. Respiration.2013;86(4):295-301.
24. Erden ES., et al. Investigation of serum bisphenol A, vitamin D, andparathyroid hormone levels in patients with obstructive sleep apneasyndrome. Endocrine. 2014;45(2):311-318.
25. Kheirandish Gozal L, et. al. Vitamin D levels and obstructive sleepapnoea in children. Sleep Med. 2014;15(4):459-463.
26. Udwadia ZF, Doshi AV, Lonkar SG. Singh C.I. Prevalence of sleepdisordered breathing and sleep apnea in middle-aged urban Indianmen. Am J Respir Crit Care Med. 2004;169(2):168-173.
27. Peterson CA, Heffernan ME. Serum tumor necrosis factor-alphaconcentrations are negatively correlated with serum 25 (OH) Dconcentrations in healthy women. J Inflamm. 2008;24(5):10.
28. McCarty DE, Reddy A, Keigley Q, et al. Vitamin D, race, and excessivedaytime sleepiness. J Clin Sleep Med. 2012;8(6):693-697.
29. Liguori C, Romigi A, Izzi F, et al. Continuous positive airway pressuretreatment increases serum vitamin D levels in male patients withobstructive sleep apnea. J Clin Sleep Med. 2015;15(11):603-607.
30. Schlosshan D, Elliott MW. Sleep. 3: clinical presentation and diagnosisof the obstructive sleep apnoea hypopnoea syndrome. Thorax. 2004;59(4):347-352.
Article available in :
Volume 2, Issue 3, 2024
Page : 45-51
https://doi.org/10.51271/JOPIC-0035
Article Information
Received : 30 Haz 2024
Accepted : 26 Tem 2024
Published : 15 Ağu 2024
Corresponding Author :

Emire Pınar Seyfettin Çelik: Department of Pulmonology, Atatürk Sanatoryum Training and Research Hospital, University of Health Sciences, Ankara, Turkiye

[email protected]
Citation : Seyfettin Çelik EP, Küpeli AE. The relationship between obstructive sleep apnea syndrome severity and vitamin D levels in sera. J Pulmonol Intens Care. 2024;2(3):45-51.

Read: 206
Cited: 0
Download : 72
_Footer