JOPIC

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine.

EndNote Style
Index
Case Report
Thromboembolic complication of nephrotic syndrome: a case of pulmonary embolism
Pulmonary thromboembolism (PTE) is a frequently encountered, difficult-to-diagnose condition with high mortality. While many risk factors such as lower extremity fractures, myocardial infarction, immobilization, and malignancy are well known, nephrotic syndrome remains a rare secondary risk factor. A 28-year-old male patient, hospitalized with a preliminary diagnosis of nephrotic syndrome, developed sudden-onset chest pain and dyspnea on the second day of admission. Although hemodynamically stable, his chest X-ray revealed increased opacity in the right lower zone, suggestive of pulmonary infarction. Elevated D-dimer levels and right heart dilatation detected by bedside echocardiography supported the suspicion of PTE, prompting the initiation of anticoagulant therapy. Pulmonary CT angiography (CTPA) confirmed acute thrombi in the right pulmonary artery and its branches along with infarct areas. This case highlights the rare coexistence of nephrotic syndrome and acute PTE in a young adult, emphasizing the importance of recognizing radiological signs and the need for awareness regarding prophylactic anticoagulation in such patients.


1. Dickson BC. Venous thrombosis: on the history of Virchow’s triad. Univ Toronto Med J. 2004;81(3):166-171.
2. Turkish Thoracic Society. Pulmonary thromboembolism diagnosis and treatment consensus report. 2021.
3. Yang Y, Lv J, Zhou F, et al. Risk factors of pulmonary thrombosis/embolism in nephrotic syndrome. Am J Med Sci. 2014;347(1):33-37. doi: 10.1097/MAJ.0000000000000315
4. Sagripanti A, Barsotti G. Hypercoagulability, intraglomerular coagulation and thromboembolism in nephrotic syndrome. Nephron. 1995;70(3):271-281. doi:10.1159/000188604
5. Ikeda S, Takaya Y, Takahashi K, et al. A case of nephrotic syndrome associated with pulmonary infarction and renal vein thrombosis. Nippon Jinzo Gakkai Shi. 1989;31(8):883-889.
6. Gordon-Cappitelli J, Choi MJ. Prophylactic anticoagulation in adult patients with nephrotic syndrome. Clin J Am Soc Nephrol. 2019;14(10): 1592-1600. doi:10.2215/CJN.05250419
7. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 clinical practice guideline for the management of glomerular diseases.Kidney Int. 2021;100(4S):S1-S276. doi:10.1016/j.kint.2021.05.021
8. De Pascali F, Brunini F, Rombolà G, Squizzato A. Efficacy and safety of prophylactic anticoagulation in patients with primary nephrotic syndrome: a systematic review and meta-analysis. Intern Med J. 2024; 54(2):214-223. doi:10.1111/imj.16227
9. Kelddal S, Nykjær KM, Gregersen JW, Birn H. Prophylactic anticoagulation in nephrotic syndrome prevents thromboembolic complications. BMC Nephrol. 2019;20(1):139. doi:10.1186/s12882-019-1336
Volume 3, Issue 2, 2025
Page : 40-43
_Footer