JOPIC
Journal of Pulmonology and Intensive Care

The JoPIC is an independent-unbiased, peer-reviewed, and open-access journal of current national and international issues and reviews for original clinical and experimental research, interesting case reports, surgical techniques, differential diagnoses, editorial opinions, letters to the editor, and educational papers in pulmonology, thoracic surgery, occupational diseases, allergology, and intensive care medicine.

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Case Report
Symptomatic unicentric castleman disease with left hilar localization: a rare case posing a diagnostic challenge
Abstract
Unicentric Castleman disease (UCD) is a rare lymphoproliferative disorder that is often detected incidentally and asymptomatically. However, in some cases, mass effect or inflammatory features may cause clinical symptoms, posing a diagnostic challenge. A 43-year-old woman with a history of toxic nodular goiter presented with dyspnea. Thoracic CT revealed a 37×29 mm well-circumscribed mass in the left hilum encasing the basal branch of the pulmonary artery. PET-CT showed moderate FDG uptake (SUVmax: 6.1). EBUS-guided biopsy reported reactive lymphoid tissue. Due to diagnostic uncertainty, surgical excision was performed. Histopathology confirmed hyaline-vascular type UCD. HHV-8-associated MCD and lymphoma were excluded. This case highlights the diagnostic complexity of UCD, especially when presenting with a symptomatic hilar mass and moderate FDG uptake mimicking malignancy. Surgical biopsy remains essential for definitive diagnosis.

Keywords : Unicentric castleman disease, hyaline-vascular type, hilar localization

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Article available in :
Volume 3, Issue 4, 2025
Page : 115-117
https://doi.org/10.51271/JOPIC-0070
Article Information
Received : 12 Ağu 2025
Accepted : 09 Kas 2025
Published : 29 Kas 2025
Corresponding Author :

Esma Sevil Akkurt: Department of Chest Diseases, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkiye

[email protected]
Citation : Atasoy A, Akkurt ES, Düvenci Birben Ö, Beyoğlu MA, Yenibertiz D. Symptomatic unicentric Castleman disease with hilar localization mimicking malignancy: a diagnostic challenge. J Pulmonol Intens Care. 2025;3(4):115-117.

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